Phendimetrazine has the capacity to suppress appetite in a large number of overweight individuals by altering the body’s metabolism. Read on to know all about this drug including its uses, dosage, interactions and side effects.

What is Phendimetrazine?

It is a common form of psychostimulant that falls under the chemical class of morpholine. The pharmacological activity of the drug is analogous to amphetamine. It stimulates the sympathetic nervous system, heightens mental alertness and increases blood flow to the muscles. It is widely used as an appetite suppressant, which reduces hunger and ultimately leads to weight loss. The drug is a Schedule III drug under the Convention on Psychotropic Substances in United States because of some serious complications associated with it. The anti-obesity pill is also called “anorectic” or “anorexigenic” drug, which means a dietary supplement.

Phendimetrazine Form

The efficacious weight loss pill is available in the following forms:


Sustained-release (SR) capsules of the drug are packaged in bottles of 100 and 1000.


The oral tablets for immediate release are available in bottles of 100 and 1000.

Phendimetrazine Use

The drug is extensively used for treating exogenous obesity caused by excessive intake of high calorie food in individuals above the age of 17. An array of obesity-related disorders can affect a large number of obese patients. The weight reducing drug works quite effectively in individuals having a body mass index of 30 or more. However, the drug only has short-term benefits and cannot be used for lifelong treatment of obesity. As a central nervous system stimulant, it increases the rate of metabolism of excess fat in the body and induces a high level of physical energy. After the intake of this medication, individuals loose the desire to eat and begin to consume food on an infrequent basis. Users of the diet pill can see its effects only for a few weeks. Adopting a diet low on calorie along with vigorous exercises is the best way to enhance the efficacy of the drug.

Phendimetrazine Ingredients

The generic drug has been approved by the FDA for its use as an effective weight loss medicine. Phendimetrazine tartrate is the active ingredient present in both capsules and tablets of the appetite suppressant, which acts directly on the central nervous system. It is a white, odorless crystalline powder and freely soluble in water. The other constituents of the weight loss pill are:

Binding agents

These components are required for binding all the drug ingredients together. Some of these include:

• Microcrystalline cellulose

• Sodium starch glycolate

• Compressible sugar

• Isopropyl alcohol

Disintegrating agent

Sodium starch glycolate is the disintegrating agent used in this drug. As the name suggests, this particular constituent expands and immediately disintegrates in the gut, causing the medicine to be adsorbed efficiently.

Filling agent

Fillers are required to make the tablet bigger, and easier to handle by both producers and consumers. Microcrystalline cellulose and lactose anhydrous are some of the filling agents used in this drug. These reagents are normally inert, water soluble, colorless and tasteless.


Lactose anhydrous, a white crystalline powder derived from whey protein is used as a potential diluent in the diet pill.

Dispersing agent

Povidone is easily soluble in water and acts as a good emulsifier.

Lubricating agent

Magnesium stearate is required for lubrication throughout the entire compounding process in the manufacturing stage. It usually prevents the ingredients from adhering to the manufacturing devices as well as the tablets or capsules from sticking to one another in the bottles.


The sweetness of the tablets can be attributed to the presence of a confectioner’s sugar.

Pure water

Purified water is needed as a mixing agent or a solvent for the other components to dissolve well.

Phendimetrazine Mechanism of action

A part of the drug metabolizes into a sympathomimetic stimulant called phenmetrazine after it enters the body. The substance has a high potential for stimulating the central nervous system to release serotonin by targeting the hypothalamus of the brain. Elevated levels of the neurotransmitter in the body detect high quantity of blood glucose, and release epinephrine and norepinephrine. These two neurotransmitters cause secretion of glucose from the liver and muscle cells, storing body fat. This is followed by burning of the accumulated fat, which reduces the urge to eat and speeds up the process of weight loss. The energy, which gets released after fat metabolism, is responsible for increasing the rate of heart activity.

Phendimetrazine Dosage

The anti-obesity drug cannot be used unless prescribed by an experienced health practitioner. It should always be taken prior to breakfast. Some patients are recommended by their physicians to have the drug two or three times a day. Generally, moderate doses of the medication yields optimal results. For adults, the standard dose is 105 mg slow release capsule or 35 mg oral tablet, consumed 30 to 60 minutes before the morning meal. However, the dose could be significantly increased in individuals who have serious obesity-related health issues. In all likelihood, the dosage must not exceed 2 tablets thrice a day.

Phendimetrazine Missed Dose

In case you miss a dose, take it as soon as you remember. However, if it is almost time for the next dose then skip the previous one.

Phendimetrazine Side effects

The psychoactive drug can trigger an allergic reaction in some users. In such a situation, an emergency medical aid is warranted. Following are some of the severe side effects of the weight loss pill:

  • Difficulty breathing
  • Skin rashes
  • Intense swelling of the ankles, feet, face, lips, tongue and neck
  • Excruciating chest pain
  • Pounding heartbeats
  • Blurred vision

Almost all users of this drug may experience some of the following less serious side effects:

  • Headaches
  • Dizziness
  • Insomnia
  • Tremors
  • Restlessness
  • Confusion
  • Anxiety
  • Flushing
  • Dry mouth
  • Diarrhea or constipation
  • Decreased libido

Phendimetrazine Overdose

Overdose of the drug could be life-threatening and may lead to complications like:

  • Increased hyperactivity
  • Hallucinations
  • Fatigue
  • Depression
  • Agitation
  • Buzzing in the ears
  • Frequent urination
  • Hypertension/Hypotension
  • Pulmonary collapse
  • Nausea
  • Abdominal cramps
  • Vomiting
  • Convulsions
  • Coma

Drug Interactions of Phendimetrazine

The anti-obesity pill may react adversely with the following agents:

  • Alcohol
  • Monoamine Oxidase Inhibitors
  • Insulin and Oral Hypoglycemic Medications
  • Adrenergic Neuron Blocking Drugs

Phendimetrazine Precautions

The drug is not suitable for individuals with diabetes mellitus or cardiac ailments. Intake of the drug by pregnant women is strictly prohibited as it may affect the growing fetus. The medication may get excreted in breast milk and harm the nursing infants. The drug should never be used by the pediatric population.

Leave your comment