What is Bontril?
It is one form of a psychoactive drug belonging to the class of morpholine. The drug is analogous to amphetamine and stimulates the sympathetic nervous system, increases mental alertness and blood flow to the muscles. It is extensively used as an appetite suppressant, which reduces an individual’s desire to consume food, leading to weight loss. It is a Schedule III drug under the Convention on Psychotropic Substances in United States and may cause some serious repercussions. Phendimetrazine is the generic name of the drug. It is also called “anorectic” or “anorexigenic” drug.
The potent weight reducing pill is available in the following forms:
Sustained-release (SR) capsules of the drug are packaged in bottles of 100 and 1000 and must be generally stored at 20° to 25°C.
The diet tablets are available in bottles of 100 and 1000 and should be carefully stored at 25°C.
The drug is specifically used for treating exogenous obesity caused by excessive intake of high calorie food in individuals above the age of 17. Overweight patients have a greater risk of developing a host of obesity-related disorders. The drug is an effective agent for reducing weight in individuals having a body mass index of 30 or more. Obese patients must bear in mind that the drug can only be used for short-term management of excess weight. It burns the accumulated fat in the body spontaneously and induces a high level of physical energy. In this way it plays the role of a central nervous system stimulant. Users of this drug do not get the urge to eat and begin to skip meals or consume food intermittently. The beneficial effects of the diet pill lasts for only a few weeks. Therefore, the efficacy of the drug can be further enhanced by resorting to a well-balanced diet along with a proper exercise regime.
The drug is a branded prescription drug approved by the FDA. Phendimetrazine tartrate is the active ingredient of the appetite suppressant, which acts directly on the central nervous system. As a psychoactive agent, it’s after affects can be extremely distressing to the users. The other ingredients present in both capsules and tablets of the drug are:
These are required for binding all the ingredients together and include the following:
- Microcrystalline cellulose
- Sodium starch glycolate
- Compressible sugar
- Isopropyl alcohol
Sodium starch glycolate is the disintegrating agent used in this drug. As the name suggests, this particular constituent expands and immediately disintegrates in the gut, causing phendimetrazine to be adsorbed efficiently.
Fillers are required to make the tablet bigger and easier to handle by both producers and consumers. Microcrystalline cellulose and lactose anhydrous are such types of filling agents used in this drug. These fillers are inert, water soluble, colorless and tasteless.
Lactose anhydrous, a white crystalline powder derived from whey protein is used as a potential diluent in the weight loss drug.
Povidone is readily soluble in water and a good emulsifier.
Magnesium stearate is required for lubrication throughout the entire compounding process in its manufacture. It basically prevents the ingredients from sticking to the manufacturing devices and the tablets or capsules from getting attached to one another in the bottles.
The sweetness of the tablets can be attributed to the presence of a confectioner’s sugar.
Purified water is mandatorily added as a mixing agent or solvents for the other ingredients.
The diet pill is manufactured by Valeant Pharmaceuticals International, Inc.
Bontril Mechanism of Action
Phendimetrazine tartrate is a white, odorless crystalline powder. Although freely soluble in water, it sparingly dissolves in warm alcohol, and insoluble in chloroform, acetone, ether and benzene. The pharmacological activity of the chemical is similar to other drugs of the morpholine chemical class, known for reducing obesity. Once Phendimetrazine enters the body, a part of it metabolizes into a substance called phenmetrazine, which has a high potential for stimulating the central nervous system to release serotonin by targeting the hypothalamus of the brain. Elevated levels of the neurotransmitter in the body sense high quantity of blood glucose, and release epinephrine and norepinephrine. These two neurotransmitters cause secretion of glucose from the liver and muscle cells, storing body fat. In this way, an increased rate of fat metabolism suppresses the feeling of hunger and fastens the process of weight loss. The energy, which gets dissociated after the burning of fat, is responsible for increasing the rate of heart activity and subsequent blood flow.
Unless recommended by a doctor, the anti-obesity drug should not be consumed. Normally, 1 tablet should be taken prior to the morning meal. Physicians could prescribe the drug either two or three times a day. The significance of the drug is more pronounced in moderate doses. The standard dosage for an adult is 17.5 mg. However, depending on the severity of condition, the dose could be increased in few individuals. Nevertheless, the dosage must not exceed 2 tablets thrice a day.
Neither larger nor smaller doses of the diet pill curb the appetite. Prolonged duration of Bontril treatment is also detrimental to the health of the consumers. Strict adherence to a physician’s instructions can yield better results. It should always be taken 30 to 60 minutes before breakfast. The slow release capsules should be swallowed as a whole and must never be crushed, broken, chewed or opened. In case, the medication does not work effectively, consulting a doctor would be advisable instead of increasing the dose as it may lead to serious consequences. Discontinuation of the drug after a long-term use may cause some discomforting withdrawal symptoms. In such cases, affected individuals should seek a healthcare expert’s advice. The lid of the bottle containing tablets must be tightly closed and kept away from moisture as well as heat.
Bontril Side Effects
The psychostimulant drug can trigger an allergic reaction in some individuals, which may need an emergency medical aid. Some of these serious side effects include:
- Difficulty breathing
- Skin rashes
- Acute swelling of the ankles, feet, face, lips, tongue and neck
- Intense chest pain
- Pounding heartbeats
- Blurred vision
There are some less serious side effects seen in almost all users of the drug. These are:
- Light headedness
- Dry mouth
- Diarrhea or constipation
- Reduced sex drive
The use of the drug is strictly prohibited for individuals with diabetes mellitus or cardiac disorders. It can react adversely with a host of anorectic agents. The drug is not safe for pregnant women as it may harm the growing fetus. In nursing mothers, the medication may get excreted in breast milk and may prove lethal to the infants. It should never be tried by pediatric patients.
Higher doses of the drug when taken by an individual without consulting a doctor can lead to the following complications:
- Increased hyperactivity
- Buzzing in the ears
- Frequent urination
- Pulmonary collapse
- Abdominal cramps
Most pharmaceutical stores sell the diet pill. However, the drug cannot be purchased without an experienced healthcare provider’s prescription. Normally, a bottle of 30 pills is around $50 and 90 tablets/capsules cost about $130 for a month supply. Online purchasing of the drug is illegal as it cannot be used unless recommended by a doctor.